An enamine controlling group for rhodium-catalyzed intermolecular hydroacylation |
| |
| Authors: | Robert N Straker Michele Formica James D Lupton Jingze Niu Michael C Willis |
| |
| Institution: | Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK |
| |
| Abstract: | An enamine-controlled hydroacylation of alkynes using a rhodium(I)/dppe catalyst system is described. The reaction is highly selective, forming the linear enaminone products as single regioisomers in all examples. In situ hydrolysis of the enamine functionality generated α-substituted 1,3-diketone products, and Lewis-acid mediated intramolecular conjugate addition of the hydroacylation products gave substituted hexahydroquinolones. |
| |
| Keywords: | Hydroacylation Catalysis Heterocycle Rhodium |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
