A novel three-component reaction for the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinolines via 1,4-dipolar cycloaddition |
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| Authors: | Nair Vijay Sreekanth A R Abhilash N Bhadbhade Mohan M Gonnade Rajesh C |
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| Affiliation: | Organic Chemistry Division, Regional Research Laboratory, CSIR, Trivandrum 695 019, India. gvn@csrrltrd.ren.nic.in |
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| Abstract: | [reaction: see text] The 1,4-dipole derived from isoquinoline and DMAD has been shown to react readily with N-tosylimines resulting in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives. |
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