Efficient microwave-assisted synthesis of 5-deazaflavine derivatives |
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| Authors: | Trilleras Jorge López Luis Gabriel Pacheco Dency José Quiroga Jairo Nogueras Manuel Torre José M de la Cobo Justo |
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| Affiliation: | Grupo de Investigación en Compuestos Heterocíclicos, Programa de Química, Facultad de Ciencias Básicas, Universidad del Atlántico, A.A.1890 Barranquilla, Colombia. jorgetrilleras@mail.uniatlantico.edu.co |
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| Abstract: | A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N?-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines. |
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