Microwave assisted synthesis of triazolobenzoxazepine and triazolobenzoxazocine heterocycles |
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| Authors: | Aubrey Ellison Robert Boyer Paul Hoogestraat Michael Bell |
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| Affiliation: | 1. Discovery Chemistry Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States;2. Department of Chemistry, University of Wisconsin, Madison, WI 53706, United States |
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| Abstract: | Intramolecular click chemistry was utilized to effect synthesis of the benzofused, triazole ring systems. The trimethylsilyl group was found to impede the reaction progress, and therefore, conditions employing in situ removal of the TMS group coupled with microwave irradiation give the penultimate targets with good conversion. |
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| Keywords: | Click chemistry 1,3-Dipolar cycloaddition Microwave Triazole |
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