A new route to the synthesis of isoxazoline derivatives from dihydropyran via cycloaddition reaction in ionic liquid |
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| Authors: | Bhaskar Chakraborty Chiran Devi Sharma |
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| Institution: | Organic Chemistry Laboratory, Sikkim Government College, Gangtok, Sikkim 737102, India |
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| Abstract: | A new approach to the synthesis and 1,3-dipolar cycloadditions of nitrones has been described from 2,3-dihydro-4H-pyran and various hydroxylamines, with electron-deficient alkynes for the synthesis of isoxazoline derivatives. Significant rate acceleration and improved yields of exclusively exo isoxazolines in 1-butyl-3-methylimidazolium based ionic liquids have been observed. Novel isoxazolines may be used as a precursor for the synthesis of variety of peptides. |
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| Keywords: | Dihydropyran derived nitrones Cycloaddition reaction Novel isoxazolines Ionic liquid Peptides |
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