An efficient four-component synthesis of dithiocarbamate derivatives |
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Authors: | Najmedin Azizi Meysam KhajehMorteza Hasani Sahar Dezfooli |
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Institution: | Chemistry & Chemical Engineering Research Center of Iran, PO Box 14335-186, Tehran, Iran |
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Abstract: | An environmentally benign, one-pot, four-component synthesis of chemically and pharmaceutically interesting dithiocarbamate derivatives is reported. The one-pot reaction of various aromatic aldehydes, ketones, aliphatic amines, and carbon disulfide, in the presence of potassium hydroxide in urea-choline chloride deep eutectic solvent or ethanol, leads to the corresponding dithiocarbamates in good to excellent yields. This method provides a convenient and time-saving strategy, with a simple work-up procedure. |
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Keywords: | Dithiocarbamate Multicomponent reaction Green chemistry Choline chloride&ndash urea Aldehydes |
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