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Iodine-catalyzed cycloalkenylation of dihydroquinolines and arylamines through a reaction with cyclic ketones under neat conditions |
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| Authors: | Jean Fotie Suraj K. Ayer Binit S. Poudel Carolyn S. Reid |
| Affiliation: | 1. Department of Chemistry and Physics, Southeastern Louisiana University, SLU 10878, Hammond, LA 70402-0878, USA;2. Department of Chemistry and Biochemistry, University of Mount Union, 1972 Clark Avenue, Alliance, OH 44601-3993, USA |
| Abstract: | An iodine-catalyzed direct cycloalkenylation of dihydroquinolines and arylamines has been developed. This method consists of a Friedel–Crafts reaction between dihydroquinolines (or arylamines) and cyclic ketones in which the double bond is selectively generated throughout the course of the reaction resulting in a direct cycloalkenylation, under neat conditions. |
| Keywords: | Dihydroquinolines and arylamines Regioselective cycloalkenylation Molecular iodine Cyclic ketones Friedel&ndash Crafts reaction |
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