Gold-catalyzed intramolecular cyclization of alkynones with pyridine anhydrobases |
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Authors: | Lokesh Pawar F Christopher Pigge |
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Institution: | Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA |
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Abstract: | 4-Alkylpyridines functionalized with alkynyl amide substituents can be converted to pyridyl-substituted lactams via Au-catalyzed cyclization at the pyridine benzylic carbon. These transformations proceed through alkylidene dihydropyridine (anhydrobase) intermediates and demonstrate the ability to utilize these species in metal-catalyzed C–C bond forming reactions. |
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Keywords: | Pyridine Anhydrobase Gold catalysis Alkyne |
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