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Pd-catalyzed allylic alkylation of thioamides |
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| Authors: | Bin Rong Lei Ding Hailei Yu Qin Yang Xuliang Liu Dongfang Xu Guisheng Li Baoguo Zhao |
| Affiliation: | 1. The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China;2. CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China |
| Abstract: | This work describes the first Pd-catalyzed allylic alkylation of thioamides. Various thioamides were efficiently α-allylated in high yields and with excellent selectivity for monoallylation under mild reaction conditions. The process not only provides a facile method for the synthesis of functionalized thioamides, but also presents a useful transformation for synthetically important thioamides. |
| Keywords: | Thioamide Allylic alkylation Allylation Palladium Catalysis |
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