Biosynthesis and antioxidant activity of 4NRC β-glycoside |
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| Authors: | Kelly CF Araújo Cordeiro Kênnia R Rezende Boniek G Vaz Wanderson Romão Luciano M Lião Eric de Souza Gil Valéria de Oliveira |
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| Institution: | 1. Faculdade de Farmácia, Universidade Federal de Goiás, Caixa Postal 131, 74.605-220 Goiânia, GO, Brazil;2. Instituto de Química, Universidade Federal de Goiás, Caixa Postal 131, 74.605-220 Goiânia, GO, Brazil;3. Departamento de Química, Universidade Federal do Espírito Santo, 29075-910 Vitória, ES, Brazil |
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| Abstract: | This Letter describes glycosylation of 4-Nerolidylcatechol (4-NRC) the major secondary metabolite from Pothomorphe peltata and Pothomorphe umbellata showing remarkable antioxidant, antimalarial, anti-inflammatory, and anti-HIV activities. One step biosynthesis was catalyzed by Cunninghamella echinulata ATCC 9245 and the reaction was undertaken in PDSM medium at 27 °C, 200 rpm for 96 h. After purification by silica gel flash column chromatography the 4-NRC β-glycoside was identified by ultrahigh resolution mass spectrometry and 1H NMR. The antioxidant activity was evaluated by differential pulse voltammetry. |
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| Keywords: | Glycosylation 4-Nerolidylcatechol Cunninghamella 4NRC-β-glycoside |
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