Water mediated deprotective intramolecular hydroamination of N-propargylaminopyridines: synthesis of imidazo[1,2-a]pyridines |
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| Authors: | Darapaneni Chandra Mohan Niraj B SarangSubbarayappa Adimurthy |
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| Institution: | Academy of Scientific & Innovative Research, CSIR–Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364 002, Gujarat, India |
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| Abstract: | Metal-free synthesis of substituted imidazole 1,2-a]pyridines from deprotective N-(prop-2-yn-1-yl)pyridin-2-amines in water is elucidated. Electron releasing substituents on pyridine ring provided pure products in quantitative yields without separation by column chromatography. |
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| Keywords: | N-propargylaminopyridines Imidazo[1 2-a]pyridine Hydroamination Synthesis Water |
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