An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy |
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| Authors: | Craig Donald Scott Boyd |
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| Affiliation: | AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK |
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| Abstract: | We have discovered a novel route for synthesising 2-alkylpyridines by exploiting the decarboxylation of pyridyl malonate esters. Herein we report the synthesis of a number of examples and describe how the reaction was discovered. |
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| Keywords: | Pyridine Decarboxylation Malonate Alkylation Alkyl halide |
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