Synthesis and antitumor activities of novel bis-quinazolin-4(3H)-ones |
| |
| Authors: | Nasrin Rahmannejadi Issa Yavari Soghra Khabnadideh |
| |
| Institution: | 1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Chemistry, Tarbiat Modares University P.O. Box 14115-175, Tehran, Iran;3. Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
| |
| Abstract: | With the aim of obtaining new antitumor agents, a series of bis-quinazolin-4(3H)-ones ( 3a-3 f ) were designed and synthesized. These products contain 4-oxo-1,2,3,4-tetrahydro-quinazoline and 3H-quinazolin-4-one moieties linked together via a propyl chain. Cytotoxic activities of 3a-3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF-7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a , 3b , and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF-7. |
| |
| Keywords: | |
|
|
