Regioselective synthesis of spiro isoxazole-oxindole-tetrahydrothiophene hybrids via cascade reactions under catalyst-free conditions |
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| Authors: | Sakkani Nagaraju Kota Sathish Neeli Satyanarayana Banoth Paplal Dhurke Kashinath |
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| Institution: | Department of Chemistry, National Institute of Technology, Warangal, -506 004, India |
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| Abstract: | Catalyst-free synthesis of the isoxazole-spirooxindole-tetrahydrothiophene hybrids is reported. Formation of 1,4-thia-Michael and intramolecular aldol reactions were observed (instead of 1,6-thia-Michael followed by vinylogous Henry reactions) in a regioselective fashion to give new isoxazole-spirooxindole-tetrahydrothiophene hybrids with excellent yields. |
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