Convenient synthesis of novel pyrimido[4,5-b][1,5]benzothiazepines |
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| Authors: | Mohsen Nikpour Neda Hasanzadeh |
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| Affiliation: | Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran |
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| Abstract: | Reaction of 4,6-dichloropyrimidine-5-carbaldehyde with amines in chloroform gave 4-(substitutedamino)-6-chloro-pyrimidine-5-carbaldehydes derivatives at low temperature. Treatment of the latter products with 2-aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11H-pyrimido[4,5-b][1,5]benzodiazepine derivatives. Structures of the products confirmed by 1HNMR, IR, and mass spectra. |
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