Synthesis of diverse (E)-2-((1H-imidazol-1-yl)methyl)-2-((benzyloxy)methyl)-2,3-dihydro-1H-inden-1-one O-benzyl oxime derivatives as potent antileishmanial agents |
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| Authors: | Santosh M Surwase Yogesh D Mane Mahesh M Surwase Bhimrao C Khade |
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| Institution: | 1. Department of Chemistry, Shri Chhatrapati Shivaji College, Omerga, India;2. BSS Arts, Science and Commerce College, Makani, India;3. Department of Chemistry, Syngene International Limited, Banglore, India;4. Department of Chemistry, Dnyanopasak College, Parbhani, India |
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| Abstract: | A series of (E)-2-((1H-imidazol-1-yl)methyl)-2-((benzyloxy)methyl)-2,3-dihydro-1H-inden-1-one O-benzyl oximes ( 6a-j ) were prepared and evaluated for their in vitro antileishmanial potency against Leishmania donovani (in promastigote and amastigote models). At a concentration of 05-μg/mL, compounds 3a-d , 4a-d , 5a , 5b , 6a-d, and 7a-d exhibited 97% to 100% and 87% to 100% inhibition against promastigotes and amastigotes, respectively. Compounds 6a , 6d-6j and 6a , 6i , 6j exhibited equal antileishmanial potency to that of SSG and Pentamidin at lower values of IC50. |
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