In vivo quantification of propylene glycol,glucose and glycerol diffusion in human skin with optical coherence tomography |
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| Authors: | X Guo Z Y Guo H J Wei H Q Yang Y H He S S Xie G Y Wu H Q Zhong L Q Li and Q L Zhao |
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| Institution: | 1.MOE Key Laboratory of Laser Life Science, Minisity of Education, and Institute of Laser Life Science,South China Normal University,Guangzhou,Guangdong Province, China;2.Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education,Fujian Normal University,Fuzhou,Fujian, China;3.Graduate School at Shenzhen,Tsinghua University,Shenzhen,Guangdong, China;4.Department of Surgery, the First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong Province, China |
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| Abstract: | The purpose of study is to quantify and compare diffusion of propylene glycol, glucose, glycerol in the human skin in vivo
noninvasively. Optical coherence tomography (OCT) was utilized in the functional imaging of optical cleaning agents for monitoring
and quantifying the permeability coefficients (PCs) of them. Our experiments showed that the permeability coefficient of 40%
propylene glycol from different subjects was averaged and found to be (2.52 ± 0.02) × 10−6 cm/s, the permeability coefficient of 40% glucose was (1.94 ± 0.05) × 10−6 cm/s, and the permeability coefficient of 40% glycerol was (1.82 ± 0.04) × 10−6 cm/s. The results indicated that the diffusion of propylene glycol solutions was faster than that of glucose solution, and
the diffusion of glucose solutions was faster than that of glycerol solutions. The dependence of the permeability on the different
hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of
tissues and cells as well as in clinical pharmacology. |
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