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Determination of pKa values of quinolones from mobility and spectroscopic data obtained by capillary electrophoresis and a diode array detector |
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| Authors: | E Jimé nez-LozanoI Marqué s,D Barró nJ.L Beltrá n,J Barbosa |
| Affiliation: | a Department of Analytical Chemistry, University of Barcelona, Avda. Diagonal, 647.08028 Barcelona, Spain b Department of Chemistry, Faculty of Science, University of Girona, Campus Montilivi, 17071 Girona, Spain |
| Abstract: | This work compares the values of dissociation constants obtained from electrophoretic mobilities of a series of quinolones at different pH values and those obtained using absorbance spectra at the maximum of the eletrophoretic peaks. The results obtained show that the two methods are complementary and constitute a valuable means of obtaining better precision. The two methods proposed can be used simultaneously without an increase in the experimental time and allow confirmation of the results obtained. |
| Keywords: | Capillary electrophoresis Diode array detector Dissociation constant |
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