| First Total Synthesis of an Analogue of (±)-Hypargenin B |
| |
| 作者姓名： | An Pai LI Hui WANG Cheng Lu ZHANG Tong Xing WU Xin Fu PAN* |
| |
| 作者单位： | An Pai LI，Hui WANG，Cheng Lu ZHANG，Tong Xing WU，Xin Fu PAN* Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 |
| |
| 基金项目： | We are grateful to the National Natural Science Foundation of China (No. 29372050) for financial support. |
| |
| 摘 要： | Hypargenin B, a diterpene with the abietane skeleton, was isolated by Ayhan from the root of an endemic species salvia hypargenia and showed antibacterial activity1. In this diterpene, the junction of A/B ring is trans. In order to provide for studying further the relationship between the structure and bioactivities, we develop a novel route whereby the hypargenin B methyl ether 22 could be obtained in good yield. To our knowledge no total synthetic work has been reported on the title com…
|
First Total Synthesis of an Analogue of (±)-Hypargenin B |
| |
| An Pai LI,Hui WANG,Cheng Lu ZHANG,Tong Xing WU,Xin Fu PAN*.First Total Synthesis of an Analogue of (±)-Hypargenin B[J].Chinese Chemical Letters,2002,13(2). |
| |
| Authors: | An Pai LI Hui WANG Cheng Lu ZHANG Tong Xing WU Xin Fu PAN |
| |
| Abstract: | First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of AC→ABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol. |
| |
| Keywords: | Hypargenin B diterpene intramolecular steroselective |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
