| 铑(I)催化的不对称硅氢化反应合成手性2-氨基-1-芳基乙醇研究 |
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| 引用本文： | 姚金水,吴佑实.铑(I)催化的不对称硅氢化反应合成手性2-氨基-1-芳基乙醇研究[J].高等学校化学学报,2002,23(1):68. |
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| 作者姓名： | 姚金水 吴佑实 |
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| 作者单位： | 1. 山东轻工业学院材料科学与工程系, 济南 250100;
2. 山东大学, 南校区, 材料科学与工程学院, 济南 250061 |
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| 基金项目： | 山东省自然科学青年基金 (批准号 :Q98B0 3119)资助 |
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| 摘 要： | 报道了以Rh()-手性2-(2-吡啶基)-4-羧甲基-1,3-噻唑烷为催化剂,2-氨基芳香酮的不对称硅氢化反应,在常温常压下手性2-氨基-1-芳基乙醇的产率几乎可达定量,产品光学纯度可达80%e.e以上.
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| 关 键 词： | 不对称硅氢化反应 手性2-氨基-1-芳基乙醇 催化 |
| 收稿时间： | 2000-09-11 |
Synthesis of α-Amino Alcohols via Rh(I)-catalytic Asymmetric Hydrosilylation of Amino Ketones |
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| YAO Jin Shui ,WU You Shi.Synthesis of α-Amino Alcohols via Rh(I)-catalytic Asymmetric Hydrosilylation of Amino Ketones[J].Chemical Research In Chinese Universities,2002,23(1):68. |
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| Authors: | YAO Jin Shui WU You Shi |
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| Institution: | 1. Department of Material Science & Engine.e.ring, Shandong Institute of Light Industry, Jinan 250100, China;
2. College of Material Science & Engine.e.ring, Shandong University(South Part), Jinan 250061, China |
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| Abstract: | The asymmetric hydrosilylation of 2 amino aryl ketones catalyzed by 2/2 (2 pyridyl) 4 carbomethoxy 1,3 thiazolidine(A) systems was first reported. The chiral 2 amino 1 aryl ethanols were obtained in nearly quantatative yield and high enantioselectivity. The reaction of fourteen 2 amino arylketones with different groups were investigated. It was found that the \%e.e.\% values were all higher than 92% when there are group(s), such as OH, OMe or Me on the phenyl group,while the optical purities were less than 85% e.e. when there are group(s) such as Cl, NO 2 on the phenyl group. In comparision with the reaction of ketones having no founctional group, the optical yield of 2 amino ketones were higher. |
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| Keywords: | Asymmetric hydrosilylation Chiral 2 amino 1 aryl ethanol Calalysis |
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