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Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies |
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| Authors: | Siddiqui Hina Baheej M A A Ullah Saeed Rizvi Fazila Iqbal Shazia Haniffa Haroon M Wahab Atia-tul Choudhary M Iqbal |
| Institution: | 1.H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan ;2.Department of Chemical Sciences, Faculty of Applied Sciences, South Eastern University, Oluvil, Sri Lanka ;3.Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan ;4.Department of Biochemistry, King Abdul Aziz University, Jeddah, 21452, Saudi Arabia ;5.Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Campus C, Surabaya, 60115, Indonesia ; |
| Abstract: | Molecular Diversity - The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of hydrochlorothiazide (1)... |
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