| A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS |
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| 作者姓名： | Yong-zhi Qiu Dou-yong Min Chi Ben Chi Ben Qiang Chen Si-cong Lin |
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| 作者单位： | [1]Research Center of Surface ＆ Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China [2]College of Chemistry ＆ Environment Science, Nanjing Normal University, Nanjing 210097, China |
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| 基金项目： | This work was support by the Special Funds for Major State Basic Research Projects of China （G1999064705）. |
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| 摘 要： | A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-（3-sulfopropyl）-aminopropyl- trimethoxysilane （DESATS）, was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.
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| 关 键 词： | 两性离子 硅烷 生物材料 分子结构 |
| 收稿时间： | 2004-10-05 |
| 修稿时间： | 2005-03-05 |
A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS |
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| Yong-zhi Qiu Dou-yong Min Chi Ben Chi Ben Qiang Chen Si-cong Lin.A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS[J].Chinese Journal of Polymer Science,2005,0(6):611-617. |
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| Authors: | Yong-zhi Qiu Dou-yong Min Chi Ben Jian Shen Qiang Chen Si-cong Lin |
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| Institution: | Research Center of Surface & Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China |
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| Abstract: | A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-(3-sulfopropyl)-aminopropyl-trimethoxysilane (DESATS), was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved. |
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| Keywords: | Zwitterionic silane coupling agent Silicone-sulfobetaine Nonthrombogenic biomaterials NONTHROMBOGENIC BIOMATERIALS SILANE COUPLING AGENT ZWITTERIONIC Platelet adhesion assay in vitro slide modified improved surface glass ESCA solution property means dynamic light scattering synthesized characterized novel |
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