GABAergic synaptic response and its opioidergic modulation in periaqueductal gray neurons of rats with neuropathic pain |
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| Authors: | Eu-Teum Hahm Younghoon Kim Jong-Ju Lee Young-Wuk Cho |
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| Institution: | (1) Department of Physiology, Biomedical Science Institute, Kyung Hee University School of Medicine, Seoul, 130-701, South Korea;(2) Department of Physiology and Biophysics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA;(3) Department of Dental Pharmacology, School of Dentistry, Kyungpook National University, Daegu, 700-412, South Korea |
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| Abstract: | Background Neuropathic pain is a chronic and intractable symptom associated with nerve injury. The periaqueductal gray (PAG) is important
in the endogenous pain control system and is the main site of the opioidergic analgesia. To investigate whether neuropathic
pain affects the endogenous pain control system, we examined the effect of neuropathic pain induced by sacral nerve transection
on presynaptic GABA release, the kinetics of postsynaptic GABA-activated Cl- currents, and the modulatory effect of μ-opioid receptor (MOR) activation in mechanically isolated PAG neurons with functioning
synaptic boutons. |
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