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Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia |
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| Authors: | Zhiyue J. Wang Roland Fischer Zili Chu Donald H. Mahoney Jr. Brigitta U. Mueller Raja Muthupillai Ellen B. James Rajesh Krishnamurthy Taylor Chung Eric Padua Elliott Vichinsky Paul Harmatz |
| Affiliation: | 1. Texas Children''s Hospital, Houston, TX 77030, USA;2. Baylor College of Medicine, Houston, TX 77030, USA;3. Children''s Hospital and Research Center Oakland, Oakland, CA 94609, USA;4. University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;5. Philips Medical Systems, Cleveland, OH 44143, USA;6. St. Luke''s Episcopal Hospital, Houston, TX 77030, USA |
| Abstract: | A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s−1) − (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level. |
| Keywords: | Iron overload Heart Thalassemia Magnetic susceptibility R2* MRI |
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