Cine-MRI and P-MRS for evaluation of myocardial energy metabolism and function following coronary artery bypass graft |
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Authors: | Zhuoli Zhang Junxia Li Shengyong Wu Ying Liu Zhaoyang Fan Xiangzhi Zhou Haitao Zhao Debiao Li Yi Huan |
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Institution: | 1. Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi''an 710032, People''s Republic of China;2. Department of Radiology, Northwestern University, Chicago, IL 60611, USA;3. Department of Cardiology, Bethune International Peace Hospital, Shijiazhuang 050082, People''s Republic of China;4. Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi''an 710032, People''s Republic of China;5. Department of Radiology, First Central Hospital of Tianjin Medical University, Tianjin 300171, People''s Republic of China |
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Abstract: | Previous studies investigated the effect of successful coronary artery bypass grafting (CABG) upon left ventricular function. The relationship between myocardial metabolism and heart function after CABG remains unclear. We investigated the relationship between high-energy phosphate (HEP) and cardiac function following CABG using cine magnetic resonance imaging (cine-MRI) and phosphorus-31 magnetic resonance spectroscopy (31P-MRS). A retrospective study was approved by the institutional review board. MRI and 31P-MRS examinations were reviewed of 37 patients with multivessel disease who underwent CABG. 13 of these patients selected for the retrospective analysis had ≥70% stenosis in the proximal left anterior descending artery (LAD) and left ventricular ejection fraction (LVEF) <40%. LVEF was evaluated using cine-MRI. HEP such as phosphocreatine (PCr) and adenosine triphosphate (β-ATP) was measured using 31P-MRS to calculate PCr/β-ATP ratio. Cine-MRI and 31P-MRS measurements were performed before and after CABG, respectively. Ten normal healthy volunteers served as controls. 31P-MRS in 13 patients showed that post-CABG PCr/β-ATP ratio was significantly higher than that of pre-CABG (pre-CABG vs. post-CABG, 1.43±0.24 vs. 1.71±0.29, P<.05), but both ratios were significantly lower than control group (2.13±0.21, P<.05). With the change of the ratio, the left ventricle function was significantly improved (LVEF: pre-CABG vs. post-CABG: 35.7±12.9 vs. 45.6±17.2, P<.05). |
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Keywords: | Phosphorus-31 magnetic resonance spectroscopy Cine magnetic resonance imaging High-energy phosphate Heart function Coronary artery bypass grafting surgery |
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