| 用氨基酸加和法计算多肽的脂水分配系数 |
| |
| 引用本文： | 陶鹏,王任小,来鲁华.用氨基酸加和法计算多肽的脂水分配系数[J].物理化学学报,1999,15(5):449-453. |
| |
| 作者姓名： | 陶鹏 王任小 来鲁华 |
| |
| 作者单位： | Institute of Physical Chemistry,Peking University,Beijing 100871 |
| |
| 摘 要： |
|
| 关 键 词： | 分配系数 疏水性 多肽 进化验证 氨基酸加和法 |
| 收稿时间： | 1998-07-01 |
| 修稿时间： | 1998-08-25 |
Calculation of Peptide's Partition Coefficients by Amino Acid Addition Model |
| |
| Tao Peng,Wang Ren-Xiao,Lai Lu-Hua.Calculation of Peptide's Partition Coefficients by Amino Acid Addition Model[J].Acta Physico-Chimica Sinica,1999,15(5):449-453. |
| |
| Authors: | Tao Peng Wang Ren-Xiao Lai Lu-Hua |
| |
| Institution: | Institute of Physical Chemistry,Peking University,Beijing 100871 |
| |
| Abstract: | Based on amino acid addition model, a set of hydrophobicity contributions of amino acids was obtained from the multivariate linear regression analysis of peptides' octanol/water partition coefficients. Multivariate regression was performed on a training set of 219 peptides including dipeptides to pentapeptides which we compose 21 natural amino acids. The correlation coefficients for the whole set fitting are 0. 978 and 0- 974, for log P and log D respectively. In addition, a new test method -evolution test-for regression analysis was discussed. The result of evolution test for amino acid addition model shows the advantage of this new test method. |
| |
| Keywords: | Partition coefficient Hydrophobicity Amino acid addition model Peptides Evolution test |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《物理化学学报》浏览原始摘要信息 |
| 点击此处可从《物理化学学报》下载免费的PDF全文 |
|
