Iodinated polyesters as a versatile platform for radiopaque biomaterials |
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| Authors: | Katelyn R Houston Sarah M Brosnan Laurel M Burk Yueh Z Lee J C Luft Valerie S Ashby |
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| Institution: | 1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;2. Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;4. Department of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina;5. Department of Chemistry, Duke University, Durham, North Carolina |
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| Abstract: | The design of polymeric biomaterials with long‐lasting X‐ray contrast could advance safe and effective implants and contrast agents. Herein, a new set of wholly aliphatic, iodinated polyesters are synthesized and evaluated as high‐contrast biomaterials and nanoparticle contrast agents for general computed tomography imaging. A single iodinated monomer is used to synthesize a variety of aliphatic polyesters with tunable thermal and mechanical properties. These iodinated polyesters are end‐functionalized with a photocurable methacrylate group, which allows easy processability. The resulting materials exhibit no cytotoxicity and are radiopaque, containing over 40% iodine by weight after processing. The polymers can be formulated into lipid–polymer hybrid nanoparticles using a modified nanoprecipitation method. Initial studies indicate that these nanoparticles show good continual contrast over 60 minutes with no uptake into the kidneys. The work presented here illustrates a novel platform for iodinated polyesters that exhibit high radiopacity and processability, low cost, and no cytotoxicity. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 2171–2177 |
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| Keywords: | contrast agents iodine nanoparticles polyesters X‐ray imaging |
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