Ligand-free copper-catalyzed regioselective C-2 arylation of imidazo[2,1-b]thiazoles |
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| Authors: | Huang Guoli Sun Hongsheng Qiu Xiaojie Jin Can Lin Chen Shen Yingzhong Jiang Juli Wang Leyong |
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| Institution: | Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. |
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| Abstract: | An effective, regioselective C-2 arylation of imidazo2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary mechanistic studies of this arylation are also reported. |
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