The Heck reaction under ball-milling conditions |
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| Authors: | Erik Tullberg Torbjörn Frejd |
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| Institution: | a Department of Organic and Bioorganic Chemistry 1, Lund University, P.O. Box 124, Lund SE-221 00, Sweden
b NeuroSearch A/S, 93 Pederstrupvej, DK-2750 Ballerup, Denmark |
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| Abstract: | The synthesis of unsaturated unnatural amino acids according to the Heck-Jeffery protocol using a ball-milling procedure is presented. NOE data recorded on the products confirm that the Z-isomer is formed. This type of mechano-chemistry provides an efficient, “solvent free” and reliable method for the synthesis of substituted dehydroalanines. These conditions provide patterns of reactivity complementary to conventional procedures. |
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| Keywords: | Palladium catalysed Heck-couplings using ball-mill grinding |
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