Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system |
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| Authors: | Qiang Ma Hua Bai Wentao Li Chao Wang Xinshi Li R Graham Cooks Zheng Ouyang |
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| Institution: | 1. Chinese Academy of Inspection and Quarantine, Beijing 100176, China;2. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA;3. Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA;4. Department of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA;5. Center for Analytical Instrumentation Development, Purdue University, West Lafayette, IN 47907, USA |
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| Abstract: | Significantly simplified work flows were developed for rapid analysis of various types of cosmetic and foodstuff samples by employing a miniature mass spectrometry system and ambient ionization methods. A desktop Mini 12 ion trap mass spectrometer was coupled with paper spray ionization, extraction spray ionization and slug-flow microextraction for direct analysis of Sudan Reds, parabens, antibiotics, steroids, bisphenol and plasticizer from raw samples with complex matrices. Limits of detection as low as 5 μg/kg were obtained for target analytes. On-line derivatization was also implemented for analysis of steroid in cosmetics. The developed methods provide potential analytical possibility for outside-the-lab screening of cosmetics and foodstuff products for the presence of illegal substances. |
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| Keywords: | Ambient ionization Slug-flow microextraction Paper spray Extraction spray Miniature ion trap mass spectrometer Cosmetics Foodstuffs Steroids Sudan Red Parabens Plasticizer |
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