Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes |
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| Authors: | Maether Marie-Pierre Bernat Virginie Maturano Marie André-Barrès Christiane Ladeira Sonia Valentin Alexis Vial Henri Payrastre Corinne |
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| Affiliation: | Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (UMR 5068), Université de Toulouse (Université Paul Sabatier), 31062 Toulouse Cedex 9, France. |
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| Abstract: | ![]()
Two series of streptocyanine dyes incorporating cyclic peroxide or 4-aminoquinoline moieties are prepared and X-ray diffraction structures for three compounds are determined. All hybrid dyes show good antiplasmodial activity (0.06 to 0.66 μM) and are not or are slightly cytotoxic, except 10a. |
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