Total synthesis of (±)-dysibetaine CPa |
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| Authors: | Masato Oikawa Shota SasakiMichihiro Sakai Ryuichi Sakai |
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| Institution: | a Graduate School of Nanobioscience, Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama 236-0027, Japan
b Faculty of Fisheries Sciences, Hokkaido University, Minato-cho, Hakodate 041-8611, Japan |
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| Abstract: | The cyclopropane-containing amino acid, dysibetaine CPa, isolated from Micronesian marine sponge, has been synthesized in 4.53% total yield over 12 steps starting from maleic anhydride to study the biological function in detail, by taking advantage of electron-withdrawing 4-nitrophenyl group. |
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| Keywords: | Dysibetaine CPa 4-Nitrophenyl group Quaternary ammonium group Neuroactive natural product Total synthesis |
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