Synthesis and spectroscopic studies of methoxy-substituted phenylthienylnicotinamidines |
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Authors: | Mohamed A Ismail Mohamed H Abdel-Rhman Ghada A Abdelwahab |
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Institution: | 1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egyptmismail@mans.edu.eg;3. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt |
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Abstract: | AbstractFive thienylnicotinamidine derivatives 5a–e were prepared from their corresponding nicotinonitriles 3a–e on treatment with lithium trimethylsilylamide LiN(TMS)2] followed by hydrolysis using ethanolic/HCl (gas). The nicotinonitriles 3a–e were prepared via Suzuki coupling reaction of bromothienyl derivative 1 with the appropriate phenylboronic acids 2a–e. The DFT calculation was used to optimize the geometric structure of the newly synthesized nicotinamidines. The comparison of DFT/B3LYP calculated spectral data (1H-NMR and 13C-NMR) with the experimental data showed acceptable agreement. Mass fragmentation patterns of 3,4-dimethoxyphenyl, 3,5-dimethoxyphenyl, and 3,4,5-trimethoxyphenyl thienylnicotinamidine derivatives were investigated. |
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Keywords: | Thienylnicotinamidines methoxyphenyl derivatives Suzuki coupling computational studies DFT |
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