Synthesis of imidazo[4,5-a]acridones and imidazo[4,5-a]acridines as potential antibacterial agents |
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| Authors: | Mohammad Rahimizadeh Mehdi Pordel Mehdi Bakavoli Zahra Bakhtiarpoor Ala Orafaie |
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| Affiliation: | (1) Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran;(2) Department of Biology, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran |
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| Abstract: | Abstract New imidazo[4,5-a]acridone derivatives were synthesized from the rearrangement of 3H-imidazo[4′,5′:3,4]benzo[c]isoxazoles. New imidazo[4,5-a]acridines were obtained from the reaction of imidazo[4,5-a]acridones in boiling POCl3. All of these compounds exhibited antimicrobial activities comparable to streptomycin as reference drug. Graphical abstract  |
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| Keywords: | Imidazo[4, 5-a]acridone Imidazo[4, 5-a]acridine Antibacterial agents Tanasescu reaction |
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