| Asymmetric reduction of α-hydroxy aromatic ketones to chiral aryl vicinal diols using carrot enzymes system |
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| 作者姓名： | Xiang Liu Yi Wang Hai Yan Gao Jian He Xu |
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| 作者单位： | School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China ; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.21176203);the National Special Fund for State Key Laboratory of Bioreactor Engineering(No.2060204);the Fundamental Research Funds for the Central Universities(No.JUSRP211A12) |
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| 摘 要： | Asymmetric reduction ofα-hydroxy aromatic ketones was carried out by using carrot enzymes system,yielding corresponding chiral vicinal diols with special functional groups.The optimum reaction conditions were obtained after investigation of various influencing factors.Chiral aryl vicinal diols were produced with good yields and excellent enantiomeric excesses under appropriate conditions.Meanwhile,the steric factors and electronic effects of the substituents on the aromatic ring were shown to have an interesting influence on both yield and enantioselectivity.
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| 关 键 词： | Asymmetric reduction Chiral aryl vicinal diol Aromatic ketone Carrot cell |
| 收稿时间： | 23 December 2011 |
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