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Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry |
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| Authors: | Ricci Camilla Nyadong Leonard Yang Felicia Fernandez Facundo M Brown Christopher D Newton Paul N Kazarian Sergei G |
| Affiliation: | aDepartment of Chemical Engineering, Imperial College London, London SW7 2AZ, UK;bSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA;cAhura Scientific Inc., Wilmington, MA 01887, USA;dWellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Vientiane, Laos;eCentre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK |
| Abstract: | Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan™) for the in situ chemical identification of counterfeit tablets is reported. |
| Keywords: | Counterfeit drugs Portable Raman spectroscopy Mass spectrometry Desorption electrospray ionization Direct analysis in real-time Malaria |
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