Synthesis,characterization, electrochemistry and evaluation of biological activities of some ferrocenyl Schiff bases |
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| Authors: | Muhammad Zaheer Afzal Shah Zareen Akhter Rumana Qureshi Bushra Mirza Misbah Tauseef Michael Bolte |
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| Institution: | 1. Department of Chemistry, Quaid‐i‐Azam University, Islamabad 45320, Pakistan;2. Department of Biochemistry, Quaid‐i‐Azam University, Islamabad 45320, Pakistan;3. Institut fur Anorganische chemie, J. W. Goethe‐Universitat Frankfurt, Max‐von‐Laue‐Strasse 7, 60438 Frankfurt/Main, Germany |
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| Abstract: | Synthesis of ferrocenyl Schiff bases ( 1–6 ) was carried out by the condensation reaction of 4‐ferrocenyl aniline with different substituted aromatic aldehydes and acetyl acetone. Compounds were characterized by physical measurements, elemental analysis, FT‐IR, 1H‐NMR and 13C‐NMR spectroscopy. Single crystal X‐ray analysis of compound 2 showed the co‐planarity of both aromatic rings connected by a C–N double bond. Compounds demonstrated reversible one‐electron redox behavior and their peak currents were found to increase linearly with the square root of the sweep rate ν1/2. The overall electrode processes were found to be diffusion controlled. Compounds 1 and 4 showed low cytotoxicity and appreciable antifungal, antioxidant and DNA protection activities. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | ferrocene Schiff bases electrochemistry biological applications |
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