| Optimization separation of five phosphoamidothioate enantiomers using a series of silica and chiral column by high-performance liquid chromatography |
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| 作者姓名： | 高如瑜 杨华铮 黄君珉 王琴孙 |
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| 作者单位： | National Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China，National Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China，National Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China，National Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China |
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| 摘 要： | A computer-assisted method is described for optimization of multi-component,mobile phase selection for separation of five phosphoamidothioate enantiomers with a series of silica and chiral columns in normal phase HPLC.The method is based on the triangular solvent selection concept using a statistical scanning method.The optimization of the separation over the experimental region is based on a special polynomial estimation from seven experimental runs,and resolution (Rs) is used as the selection criterion.Excellent agreement was obtained between predicted and experimental data.
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Optimization separation of five phosphoamidothioate enantiomers using a series of silica and chiral column by high-performance liquid chromatography |
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| GAO,Ru-Yu YANG,Hua-ZhengHUANG,Jun-Min WANG,Qin-SunNational Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin ,China.Optimization separation of five phosphoamidothioate enantiomers using a series of silica and chiral column by high-performance liquid chromatography[J].Chinese Journal of Chemistry,1998,16(2):145-152. |
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| Authors: | GAO Ru-Yu YANG Hua-ZhengHUANG Jun-Min WANG Qin-SunNational Laboratory of Elemento-Organic Chemistry Nankai University Tianjin China |
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| Institution: | GAO,Ru-Yu YANG,Hua-ZhengHUANG,Jun-Min WANG,Qin-SunNational Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China |
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| Abstract: | A computer-assisted method is described for optimization of multi-component,mobile phase selection for separation of five phosphoamidothioate enantiomers with a series of silica and chiral columns in normal phase HPLC.The method is based on the triangular solvent selection concept using a statistical scanning method.The optimization of the separation over the experimental region is based on a special polynomial estimation from seven experimental runs,and resolution (Rs) is used as the selection criterion.Excellent agreement was obtained between predicted and experimental data. |
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| Keywords: | Enantioseparation phosphoamidothioates microcomputer |
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