4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate

Authors:	I. V. Ukrainets N. L. Bereznyakova G. P. Petyunin I. A. Tugaibei V. B. Rybakov V. V. Chernyshev A. V. Turov

Affiliation:	(1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) M. V. Lomonosov Moscow State University, Moscow, 119899, Russia;(3) Taras Shevchenko National University, Kiev, 01033, Ukraine

Abstract:	An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to ¹H and ¹³C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 864–876, June, 2007.

Keywords:	2-aminopyridines heterocyclic tricarbonylmethane derivatives 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids esters X-ray analysis
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