Alumina catalyzed reactions of amino acids |
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Authors: | Bujdák J Rode B M |
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Institution: | (1) Institute of Inorganic Chemistry, Slovak Academy of Sciences, 845 36 Bratislava, Slovakia;(2) Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, 6020 Innsbruck, Austria |
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Abstract: | Thermal reactions of glycine (Gly), alanine (Ala), leucine (Leu), valine (Val) and proline (Pro) adsorbed on activated alumina
were studied by means of thermal analysis. In the absence of alumina, decomposition of amino acids was detected as a sharp
endotherm above 200°C, whereas no thermal effects were detectable by differential thermal analysis (DTA) and differential
scanning calorimetry (DSC) for amino acid/alumina mixtures. This could be explained by a continuous amino acid condensation
to peptides and simultaneous absorption of formed water by alumina, the latter being gradually released at higher temperatures.
Thermogravimetry (TG) and differential thermogravimetry (DTG) measurements revealed that the reactions of the amino acids
adsorbed on alumina surface were spread over a wide range of temperatures. The catalysis of peptide bond formation on alumina
surface at 85°C was proven directly by the identification of the reaction products, mainly dipeptides and cyclic anhydrides.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | peptide bond formation amino acids activated alumina thermal analysis |
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