Application of thermal analysis in study of binary mixtures with metformin |
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Authors: | Ana Flávia Oliveira Santos I D Basílio Jr F S de Souza A F D Medeiros Márcia Ferraz Pinto D P de Santana R O Macêdo |
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Institution: | 1. Pharmaceutical Sciences Department, Federal University of Pernambuco, UFPE, Prof. Moraes Rego Avenue, 1235, University City, Zip. 50670-901, Recife, PE, Brazil 2. Unified Laboratory of Medicine Development and Assay, LUDEM, Federal University of Paraiba, UFPB, Campus I, Zip. 58059-900, Jo?o Pessoa, PB, Brazil
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Abstract: | Thermal analysis is an essential analytical tool in development of new formulations as well as to study the interaction between drugs and excipients. This work aims to investigate the possible interactions between metformin and excipients as microcrystalline cellulose (Microcel MC101®), starch sodium glycolate (Explosol®), sodium croscarmellose (Explosel®), PVP K30, magnesium stearate, starch and lactose, usually employed in pharmaceutical products. TG, DSC and DTA techniques were used for the thermal characterization to track if the thermal properties of the drug substance were modified in the mixture. Disregard of the starch and lactose systems, no changes in thermal behavior of mixtures were found. Thermogravimetric studies (TG) of metformin and its binary mixtures showed different thermal behavior. |
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Keywords: | compatibility metformin thermal analysis |
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