S-alkyl dithioformates as 1,3-dipolarophiles. Generation of C(2)-unsubstituted penems |
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| Authors: | Sanchez Sylvie Bateson John H O'Hanlon Peter J Gallagher Timothy |
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| Institution: | School of Chemistry, University of Bristol, Bristol BS8 1TS, UK. |
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| Abstract: | S-Alkyl dithioformates, generated by a cycloreversion process, react as 1,3-dipolarophiles with beta-lactam-based azomethine ylids to provide, after (net) elimination of MeSH, C(2)-unsubstituted penems. The overall cycloreversion/cycloaddition sequence was accelerated by microwave irradiation. reaction: see text] |
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