Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst |
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| Authors: | McIntosh John A Robertson Charles R Agarwal Vinayak Nair Satish K Bulaj Grzegorz W Schmidt Eric W |
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| Affiliation: | Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA. |
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| Abstract: | A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters. |
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