New Antioxidant Phenolic Glucosides from Viburnum dilatatum |
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| Authors: | Bin Wu Saiwei Wu Haibin Qu Yiyu Cheng |
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| Affiliation: | 1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.?R. China, (phone: +86‐571‐87951138;2. fax: +86‐571‐87951138) |
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| Abstract: | ![]()
Chemical investigation of the fruits of Viburnum dilatatum Thunb. resulted in the isolation and characterization of four new phenolic glycosides, jiamiziosides A–D ( 1 – 4 ), together with five known compounds. Their structures were established by spectroscopic means and by comparison with the literature values. The antioxidant activities of the new isolates were determined against 2,2‐diphenyl‐1‐picrylhydrazyl (=2,2‐diphenyl‐1‐(2,4,6‐trinitrophenyl)hydrazinyl; DPPH) and superoxide radicals. Among the compounds tested, jiamizioside C ( 3 ) possesses the most potent inhibitory scavenging effect on DPPH and superoxide radicals with IC50 values of 16.8 and 17.8 μM , respectively. |
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| Keywords: | Glycosides Phenolic glycosides Viburnum dilatatum Antioxidant activity Jiamiziosides A – D |
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