Synthesis and Bioactivity of Novel N,N′‐Diacylhydrazine Derivatives Containing Furan(I) |
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| Authors: | Zi‐Ning CUI Juan HUANG Ying LI Yun LING Xin‐Ling YANG Fu‐Heng CHEN |
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| Institution: | Key Laboratory of Pesticide Chemistry and Application Technology, Ministry of Agriculture, Department of Applied Chemistry, College of Science,China Agricultural University, Beijing 100094, China |
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| Abstract: | The furan ring system possesses electron‐rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5‐fluorophenyl‐2‐furoyl chloride with substituted benzoylhydrazide in anhydrous dichloromethane under reflux. The structures of the resultant compounds were confirmed by IR, 1H NMR, MS and elemental analysis. Insecticidal and anti‐tumor activities of these new compounds were evaluated. |
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| Keywords: | fluorophenyl N N′ ‐diacylhydrazine furan insecticidal activity anti‐tumor activity |
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