Three Escin‐Like Triterpene Saponins: Assamicins VI,VII, and VIII from the Seeds of Aesculus assamica Griff |
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| Authors: | Hong‐Wei Liu Man‐Yuan Wang Xue‐Ying Song Ying Xia Yi‐Song Zhao Xiao‐Hong Song Miao‐Miao Jiang Xue Zhang Hao Gao Nai‐Li Wang Xin‐Sheng Yao |
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| Institution: | 1. School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Xi Tou Tiao 10#, You An Men, Beijing 100069, P.?R. China, (phone: 86‐10‐83911657;2. fax: 86‐10‐83911533);3. School of Traditional Chinese Medicine, Capital Medical University, Xi Tou Tiao 10#, You An Men, Beijing 100069, P.?R. China;4. Department of Natural Products Chemistry 81#, Shenyang Pharmaceutical University, 103 Wenhua Avenue, Shenyang 110016, P.?R. China |
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| Abstract: | Three new escin‐like triterpene saponins, assamicins VI ( 1 ), VII ( 2 ), and VIII ( 3 ), were isolated from the seeds of A. assamica, together with a known saponin, isoescin Ib ( 4 ). Their structures were established as 28‐O‐acetyl‐21‐O‐(3,4‐di‐O‐angeloyl‐6‐deoxy‐β‐glucopyranosyl)‐3‐O‐{O‐β‐glucopyranosyl‐(1→2)‐O‐β‐glucopyranosyl‐(1→4)]‐β‐glucopyranuronosyl}protoaescigenin ( 1 ), 21‐O‐angeloyl‐3‐O‐{O‐α‐rhamnopyranosyl‐(1→2)‐O‐β‐glucopyranosyl‐(1→3)]‐β‐glucopyranuronosyl}protoaescigenin ( 2 ), and 21‐O‐angeloyl‐3‐O‐{O‐β‐glucopyranosyl‐(1→3)]‐β‐glucopyranuronosyl}protoaescigenin ( 3 ) on the basis of spectroscopic analysis (protoaescigenin=(3β,4β,16α,21β,22α)‐olean‐12‐ene‐3,16,21,22,23,28‐hexol; angelic acid=(2Z)‐2‐methylbut‐2‐enoic acid). |
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| Keywords: | Aesculus assamica Triterpene saponins Escin Saponins Glycosides Assamicins VI – VIII |
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