Six New Dammarane Triterpenoids from Viburnum cylindricum |
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| Authors: | Lin Tu Yu Zhao Zu‐Yin Yu Yu‐Wen Cong Gang Xu Li‐Yan Peng Peng‐Tao Zhang Xiao Cheng Qin‐Shi Zhao |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P.?R. China, (phone: +86‐871‐5223058;2. fax: +86‐871‐5215783);3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, P.?R. China;4. Beijing Institute of Radiation Medicine, Beijing 100850, P.?R. China |
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| Abstract: | One new dammarane triterpenoid, cylindrictone A ( 1 ), as well as five new nor‐dammarane triterpenoids cylindrictone B–F ( 2 – 6 ) were isolated from the leaves of Viburnum cylindrium, together with three known compounds 3β‐hydroxy‐hexanordammaran‐20‐one ( 7 ), 3α‐hydroxyoctanordammar‐12‐en‐17‐one ( 8 ), and neoalsogenin B ( 9 ). Their structures were identified by extensive NMR‐spectroscopic (especially 2D‐NMR) and mass‐spectrometric experiments, and the structure of 3 was further confirmed by a single‐crystal X‐ray analysis. The compounds exhibited no activity against human promyelocytic leukemia HL60 cell. |
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| Keywords: | Viburnum cylindricum Dammarane triterpenoids Triterpenoids Cylindrictones A – F X‐Ray crystallography |
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