Determination of Rifampicin by Peroxomonosulfate‐Cobalt(II) Chemiluminescence System |
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| Authors: | Yong MA Bo‐Tao ZHANG Li‐Xia ZHAO Guang‐Sheng GUO Jin‐Ming LIN |
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| Institution: | 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco‐environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;2. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China;3. Tel.: & Fax: 0086‐010‐62841953;4. Department of Chemistry, Tsinghua University, Beijing 100084, China |
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| Abstract: | Rifampicin can enhance the chemiluminescence (CL) of peroxomonosulfate‐cobalt(II) system, and the CL intensity is strongly dependent on the rifampicin concentrations. Based on this phenomenon, a rapid and sensitive flow injection CL method was developed for the determination of rifampicin. The relative CL intensity was linear with the rifampicin concentration over the range of 5×10?8 to 1×10?6 g·mL?1 (r=0.9991), the detection limit was 7×10?9 g·mL?1 (S/N=3), and the relative standard deviation was 2.7% for 6×10?7 g·mL?1 rifampicin (n=11). Furthermore, this method was successfully applied to the determination of rifampicin in real eye drop and capsules sample. |
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| Keywords: | chemiluminescence peroxomonosulfate rifampicin cobalt(II) flow injection analysis |
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