Unusual Nortriterpenoid Saponins from Stauntonia chinensis |
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| Authors: | Hao Gao Zhao Wang Zhi‐Hong Yao Ning Wu Hua‐Jin Dong Jin Li Nai‐Li Wang Wen‐Cai Ye Xin‐Sheng Yao |
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| Institution: | 1. Key Lab for New Drugs Research of TCM, Shenzhen Research Institute of Tsinghua University, Shenzhen 518055, P.?R. China (phone/fax: +86‐755‐26957685);2. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P.?R. China;3. Medicine School and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, P.?R. China;4. Institute of Pharmacology & Toxicology, Academy of Military Medical Sciences, Beijing 100850, P.?R. China |
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| Abstract: | Four new saponins, yemuosides YM17–YM20 ( 1 – 4 , resp.), were isolated from the rattan of Stauntonia chinensis DC. (Lardizabalaceae) along with a known saponin, nipponoside D ( 5 ). Their structures were elucidated by spectroscopic analysis and chemical evidence as 20,30‐dihydroxy‐29‐noroleanolic acid 28‐O‐α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranosyl ester ( 1 ), 20,29‐dihydroxy‐30‐noroleanolic acid 28‐O‐α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranosyl ester ( 2 ), 29‐hydroxy‐30‐norolean‐20(21)‐enolic acid 28‐O‐α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranosyl ester ( 3 ), 29‐hydroxyoleanolic acid 28‐O‐α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranosyl ester ( 4 ), and 23,29‐dihydroxyoleanolic acid 28‐O‐α‐L ‐rhamnopyranosyl‐(1→4)‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranosyl ester ( 5 ). Yemuoside YM17–YM19 ( 1 – 3 , resp.) contain novel unusual nortriterpene aglycones. |
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| Keywords: | Stauntonia chinensis Nortriterpenoid saponins Saponins Yemuosides YM17 – YM20 |
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