Pyrrolizidine Alkaloids and Bisabolane Sesquiterpenes from the Roots of Ligularia cymbulifera |
| |
| Authors: | Chun‐Mei Liu He‐Xiang Wang Shi‐Lei Wei Kun Gao |
| |
| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, P. R. China, (phone: +86‐931‐8912592;2. fax: +86‐931‐8912582) |
| |
| Abstract: | The new pyrrolizidine alkaloid glycoside 1 , and the three new highly oxygenated bisabolane sesquiterpenes 4 – 6 , together with the two known pyrrolizidine alkaloids 2 and 3 , were isolated from the roots of Ligularia cymbulifera (W. W. Smith ) Hand .‐Mazz . Their structures were established on the basis of spectroscopic analysis, especially 1D‐ and 2D‐NMR data. The cytotoxic activities of compounds 1, 2 , and 4 – 6 were evaluated against hepatoma (BEL‐7402), human leukemia (HL‐60), human ovarian carcinoma (HO‐8910), and nasopharyngeal carcinoma (KB) cell lines (Tables 1–3). Compound 6 s howed weak cell‐growth inhibition of BEL‐7402 cell. |
| |
| Keywords: | Ligularia cymbulifera Pyrrolizidine alkaloids Alkaloids Bisabolane sesquiterpenes Sesquiterpenes |
|
|
